Synthesis, Characterization and Antimicrobial Screening of Sulphonamide Based 1, 3, 4-Oxadiazoles

Synthesis, In vitro Antimicrobial and Cytotoxic Activities of Some Novel Bis- 1, 3, 4-oxadiazoles

A series of novel bis-1,3,4-oxadizaoles were synthesized by oxidative cyclisation of respective Schiff bases derived from dicarbohydrazide using ceric ammonium nitrate (CAN) as catalyst. The synthesized compounds were screened for in vitro antibacterial activity against Staphylococcus aureus (MTCC 87), Escherichia coli (MTCC 46) and antifungal activity against Candida albicans (NCIM 3471) by tw...

synthesis, in vitro antimicrobial and cytotoxic activities of some novel bis- 1, 3, 4-oxadiazoles

Synthesis of N, N΄3, 4-Dialkylamino-1, 2, 5-Oxadiazoles

N, N΄-3, 4-di(methylamino)-1, 2, 5-oxadiazole (1f) was prepared by dehydration of N, N΄-3, 4-di(methylamino)glyoxime (2f) in aqueous potassium hydroxid at 170-180 ˚C. Under similar conditions N, N΄-3, 4-di(benzylamino)-1, 2, 5-oxadiazole (1c) and N, N΄-3, 4-di(isopropylamino)...

synthesis and characterization of some macrocyclic schiff bases

ماکروسیکلهای شیف باز از اهمیت زیادی در شیمی آلی و دارویی برخوردار می باشند. این ماکروسیکلها با دارابودن گروه های مناسب در مکانهای مناسب می توانند فلزاتی مثل مس، نیکل و ... را در حفره های خود به دام انداخته، کمپلکسهای پایدار تولید نمایند. در این پایان نامه ابتدا یک دی آلدئید آروماتیک از گلیسیرین تهیه می شود و در مرحله بعدی واکنش با دی آمینهای آروماتیک و یا آلیفاتیک در رقتهای بسیار زیاد منجر به ت...

Synthesis, Characterization and Pharmacological Screening of Substituted Sulphonamide Derivatives

Sulphonamides are an important class of heterocyclic compounds which possess wide spectrum of biological properties.The present work deals with the synthesis of some novel Sulphonamide derivatives using acetanilide, chlorsulphonic acid and various aromatic amines. All the synthesized compounds were characterized by IR, 1 H NMR and 13 C NMR Spectroscopy. The compounds were evaluated for their an...